Michal R. Schweiger

Status:
Lichtenberg Professor
Address:
University Hospital Cologne
Epigenomics Institute
Weyertal 115b
50937 Cologne
Phone: +49 221/478 96846
E-Mail: mschweig@uni-koeln.de
Nationality: German, Austria


Education

1994-2001 Medical school, Free University of Berlin; Charité University Hospital; Leopold Franzens University Innsbruck
2007-2008 MD Thesis, department of Pathology, Harvard Medical School, Boston USA; Entitled: "the interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis." advisor: Prof. PM. Howley (Summa cum laude)
1995-2002 Biochemistry studies, Free University of Berlin and Leopold Franzens University Innsbruck
2001-2002 Diploma thesis, department of Clinical chemistry, leopold-Franzens University innsbruck; Entitled: Das Proteinkinase C-Inhibitor-Protein (PKCl-1):" Wirkung auf die Proteinkinase C-Aktivität, das Ubiquitin-system und die Transkription`Advisor: prof. H. Grunicke (sehr gut)
2003-2005 PhD thesis, department of Pathology, harvard medical School, Boston USA; Entitled: Regulation of the human papillomavirus E2 transcription factor by its interaction with the cellular Bromodomain protein Brd4" Advisor: Prof. PM. Howley (Summa cum laude)


Professional and research experience

2015 Attending Physician, Human Genetics, University Hospital Cologne
2015 Board Exam (Human Genetics)
2014 Lichtenberg Professor for Translational Epigenomics, University Hospital Cologne
2008 Habilitation for Experimental Medicine, Medical Faculty, Charité University Hospital
2008-2014 Junior Research Group Leader 'Cancer Genomcs', Max-Planck Institute for Molecular Genetics, Department vertrebrate genomics, Berlin
2008-2014 Residency in Medical Genetics, Charité Hospital Berlin
2005-2007 Postdoctoral Associate, Harvard medical School Boston, Advisor: Prof. PM Howley
1999-2002 Teaching Assistant (Tutor) in Biochemistry for Medical Students and Molecular Biology for Informaticians
1998-1999 Student Research training program at the MPI for Molecular genetics (Dep. Lehrach)


Awards and honours (selected)

2014 W2 Lichtenberg Professorship of the Volkswagen Foundation
2008 Robert Koch Charité Dissertationaward
2003-2005 Scholarship Studienstiftung des deutschen Volkes
1995 1st Place "Jugend Forscht" (region and land), special price environmental technology: "Hefe (saccharomyces cerevisiae)- Ein biologischer Monito für Schutz und schaden."


List of the five most important publications

  1. Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL,            Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E,          Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de      Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M.: Telomerase activation by genomic rearrangements in high-risk Neuroblastoma Nature. 2015 Oct 29;526(7575):700-4.
  2.  Hussong M, Börno ST, Kerick M, Wunderlich A, Franz A, Sültmann H, Timmermann B, Lehrach H, Hirsch-Kauffmann M, Schweiger MR: The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. Cell Death Dis. 2014 Apr 24;5:e1195.
  3.  Börno ST, Fischer A, Kerick M, Fälth M, Laible M, Brase JC, Kuner R, Dahl A, Grimm C, Sayanjali B, Isau M, Röhr C, Wunderlich A, Timmermann B, Claus R, Plass C, Graefen M, Simon R, Demichelis F, Rubin MA, Sauter G, Schlomm T, Sültmann H, Lehrach H, Schweiger MR: Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation. Cancer Discov. 2012 Nov;2(11):1024-35.
  4.  Kerick M, Isau M, Timmermann B, Sültmann H, Herwig R, Krobitsch S, Schaefer G, Verdorfer I, Bartsch G, Klocker H, Lehrach H, Schweiger MR.: Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. BMC Med Genomics. 2011 Sep 29;4:68
  5.  Krawitz PM*, Schweiger MR*, Rödelsperger C, Marcelis C, Kölsch U, Meisel C, Stephani F, Kinoshita T, Murakami Y, Bauer S, Isau M, Fischer A, Dahl A, Kerick M, Hecht J, Köhler S, Jäger M, Grünhagen J, de Condor BJ, Doelken S, Brunner HG, Meinecke P, Passarge E, Thompson MD, Cole DE, Horn D, Roscioli T, Mundlos S, Robinson PN: Identity-by-descent  filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Nat Genet. 2010 Oct;42(10):827-9. *equal contribution