Lukas P. Frenzel

Status: Independent Research Group Leader
Address: Clinic I of Internal Medicine
University Hospital Cologne
Kerpenerstr. 62
50937 Cologne
Phone: +49 221/478 84127
Nationality: German


2002-2008 Medical School, University of Cologne, Germany
2009 MD thesis, Institute of Neurophysiology, University of Cologne. Entitled: Role of KKG2D Ligands  and ICAM-1 in NK cell-mediated lysis of Murine Embryonic Stem Cells and Embryonic Stem Cell-derived Cardiomyocytes; Advisor: Prof. Dr. J. Hescheler and Dr. Dr. T. saric; Grade: Summa cum laude

Professional and research experience

2016 Head of the Roche-CIO (Center for Integrated Oncology) Joint Research Group
2012 Independent Research Group Leader of the Apoptosis Signalling and Therapy resistance Group at the CECAD and Clinic I of Internal medicine of the University Hospital of Cologne
2011 Principal Investigator and full Member of the Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD)
2009-2011 Postdoctoral Fellow, University of Cologne, Advisor:Prof. Dr. C. Wendtner

Awards and honours (selected)

2006-2008 Research fellowship by the Köln Fortune Program

List of the five most important publications


  1. Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP. miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in chronic lymphocytic leukemia. Blood. 2015 Feb.
  2. Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel LP. Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia. 2015 Apr;29(4):981-984.
  3. Pallasch CP, Leskov I, Braun CJ, Vorholt D, Drake A, Soto-Feliciano YM, Bent EH, Schwamb J, Iliopoulou B, Kutsch N, van Rooijen N, Frenzel LP, Wendtner CM, Heukamp L, Kreuzer KA, Hallek M, Chen J, Hemann MT. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell. 2014 Jan 30;156(3):590-602.
  4. Schwamb J, Feldhaus V, Baumann M, Patz M, Brodesser S, Brinker R, Claasen J, Pallasch CP, Hallek M, Wendtner CM, Frenzel LP. B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides. Blood. 2012 Nov 8;120(19):3978-85.
  5. Baer C*, Claus R*, Frenzel LP*, Zucknick M, Park YJ, Gu L, Weichenhan D, Fischer M, Pallasch CP, Herpel E, Rehli M, Byrd JC, Wendtner CM, Plass C. Extensive promoter DNA hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia. Cancer Res. 2012 Aug 1;72(15):3775-85. (* equal contribution)