Frank Thomas Wunderlich


Independent Research Group Leader


Max Planck Institute for Metabolism Research
Gleuelerstr. 50
50931 Cologne

Phone: +49 221/4726 678
Nationality: German




Undergraduate studies in Biology, University of Mainz, University of Cologne


PhD thesis, Department of Immunology, University of Cologne. Entitled: Generation of inducible Cre systems for conditional gene inactivation in mice. Advisor: Prof. Dr. K. Rajewsky


Professional and research experience


Postdoctoral Fellow, CBR Institute for biomedical research Inc., Harvard medical school, Boston, USA, Advisor: Prof. Dr. K. Rajewsky.


Postdoctoral Fellow, Department of mouse genetics and metabolism, Institute for Genetics, University of Cologne, Germany, Advisor: Prof. Dr. Jens C. Brüning.


Leibniz Junior Research Groupleader at the Institute for Genetics, University of Cologne, Germany.


Habilitation for Genetics at the University of Cologne, Germany


Groupleader at the Max Planck Institute for Metabolism Research Cologne, Germany (W2 Position).


Scientific Societies

American Society of Gene and Cell Therapy (ASGCT)

European Society of Gene and Cell Therapy (ESGCT)

German Society for Gene Therapy (DG-GT e.V.)


List of the five most important publications

  1. Gruber S, Straub BK, Ackermann PJ, Wunderlich CM, Mauer J, Seeger JM, Büning H, Heukamp L, Kashkar H, Schirmacher P, Brüning JC, Wunderlich FT. (2013) Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling. Cell Rep. Aug 29;4(4):669-80.

  2. Wunderlich CM, Delić D, Behnke K, Meryk A, Ströhle P, Chaurasia B, Al-Quraishy S, Wunderlich F, Brüning JC, Wunderlich FT (2012). Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. Journal of Immunology 188(9):4141-4.

  3. Wendorff AA†, Koch U†, Wunderlich FT†, Wirth S, Dubey C, Brüning JC, Macdonald HR, Radtke F (2010). Hes1 is a critical but context-dependent mediator of canonical notch signaling in lymphocyte development and transformation. Immunity 33 (5): 671-84. † the authors equally contributed to this work

  4. Wunderlich FT, Ströhle P, Könner AC, Gruber S, Tovar S, Brönnecke HS, Juntti-Berggren L, Li LS, van Rooijen N, Libert C, Berggren PO, Brüning JC (2010). Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves insulin sensitivity. Cell Metab. 12 (3): 237-49.

  5. Hövelmeyer N†, Wunderlich FT†, Massoumi R, Jakobsen CG, Song J, Wörns MA, Merkwirth C, Kovalenko A, Aumailley M, Brüning JC, Strand D, Galle PR, Wallach D, Fässler R, Waisman A (2007). Regulation of B cell homeostasis and activation by the tumor suppressor gene Cyld. J Exp Med. 204 (11): 2615-27. † the authors equally contributed to this work.