Thorsten Hoppe

Status: Professor (W3)

Institute for Genetics, CECAD Research Center
University of Cologne
Joseph-Stelzmannstr. 26
50674 Cologne

Phone: +49 221/478 84218
Nationality: German





Study of Biology at the Westfälische Wilhelms-University, Münster and the the Center for Molecular Biology (ZMBH), Heidelberg


Diploma in Biology (University of Heidelberg), ZMBH, Heidelberg: Supervisor: Prof. Dr. Stefan Jentsch


Ph.D. in Molecular Biology; ZMBH, Heidelberg and Max Planck Institute of Biochemistry, Munich; Title: “Activation of a Membrane-Bound 

Transcription Factor by the Ubiquitin/Proteasome-System”. Supervisor: Prof. Dr. Stefan Jentsch


Professional and Research Experience


Postdoctoral research fellow in the Department of Molecular Neurogenetics, Gene Center Ludwig Maximilian University


Postdoctoral Associate (C1) in the Department of Molecular Neurogenetic, Adolf-Butenandt-Institute Ludwig Maximilian University, Munich


Group Leader at the Centre for Molecular Neurobiology (ZMNH), Hamburg

Since Dec. 2008

Full Professor at the Institute for Genetics, University of Cologne, and CECAD Cologne


Acting director of the Institute for Genetics

Research focus 

Protein Degradation in Development and Aging


Awards and Prizes


MPIB Junior Research Award 2001 of the Max Planck Institute of Biochemistry, Munich, for outstanding research in cell biology and biochemistry


Werner Otto Research Award 2007 for outstanding biomedical research


EMBO Young Investigator Award


Walter-Fleming-Medal of the German Society for Cell Biology (DGZ)


 Awarded ERC Consolidator Grant


 Max-Delbrück Award for Life Sciences, University of Cologne


Scientific Societies

Member of the German Society for Aging Research (DGfA)

Member of the german Society for Biochemistry and Molecular Biology (GBM)


List of the most important original publications (up to 5 publications)

1. Segref A, Kevei E, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T (2014). Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab. 19, 642-52.

2. Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T*,   Clausen T.* (2013). The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell 152, 183-95. (*co-corresponding author)

3. Kuhlbrodt K, Janiesch PC, Kevei E, Segref A, Barikbin R, Hoppe T (2011). The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat. Cell Biol. 13, 273-81.

4. Hoppe T, Cassata G, Barral JM, Springer W, Hutagalung AH, Epstein HF, Baumeister R. (2004). Regulation of the Myosin-Directed Chaperone UNC-45 by a Novel E3/E4-Multiubiquitylation Complex in C. elegans. Cell 118, 337-49.

5. Hoppe T, Matuschewski K, Rape M, Schlenker S, Ulrich HD, Jentsch S. (2000). Activation of    a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent     Processing. Cell 102, 577-586.