Thorsten Hoppe

Status: Professor (W3)
Address:

Institute for Genetics, CECAD Research Center
University of Cologne
Joseph-Stelzmannstr. 26
50674 Cologne

Phone: +49 221/478 84218
E-Mail: thorsten.hoppe@uni-koeln.de
Nationality: German

 

Education

 

1991-1995    

Study of Biology at the Westfälische Wilhelms-University, Münster and the the Center for Molecular Biology (ZMBH), Heidelberg

1996

Diploma in Biology (University of Heidelberg), ZMBH, Heidelberg: Supervisor: Prof. Dr. Stefan Jentsch

1996-2000

Ph.D. in Molecular Biology; ZMBH, Heidelberg and Max Planck Institute of Biochemistry, Munich; Title: “Activation of a Membrane-Bound 

Transcription Factor by the Ubiquitin/Proteasome-System”. Supervisor: Prof. Dr. Stefan Jentsch

 

Professional and Research Experience

02/01-07/01 

Postdoctoral research fellow in the Department of Molecular Neurogenetics, Gene Center Ludwig Maximilian University

08/01-07/03

Postdoctoral Associate (C1) in the Department of Molecular Neurogenetic, Adolf-Butenandt-Institute Ludwig Maximilian University, Munich

08/03-2008 

Group Leader at the Centre for Molecular Neurobiology (ZMNH), Hamburg

Since Dec. 2008

Full Professor at the Institute for Genetics, University of Cologne, and CECAD Cologne

2011-2013

Acting director of the Institute for Genetics

Research focus 

Protein Degradation in Development and Aging

 

Awards and Prizes

2001

MPIB Junior Research Award 2001 of the Max Planck Institute of Biochemistry, Munich, for outstanding research in cell biology and biochemistry

2007

Werner Otto Research Award 2007 for outstanding biomedical research

2007

EMBO Young Investigator Award

2008

Walter-Fleming-Medal of the German Society for Cell Biology (DGZ)

2013

 Awarded ERC Consolidator Grant

2016

 Max-Delbrück Award for Life Sciences, University of Cologne

 

Scientific Societies

Member of the German Society for Aging Research (DGfA)

Member of the german Society for Biochemistry and Molecular Biology (GBM)

 

List of the most important original publications (up to 5 publications)

1. Segref A, Kevei E, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T (2014). Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab. 19, 642-52.

2. Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T*,   Clausen T.* (2013). The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell 152, 183-95. (*co-corresponding author)

3. Kuhlbrodt K, Janiesch PC, Kevei E, Segref A, Barikbin R, Hoppe T (2011). The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat. Cell Biol. 13, 273-81.

4. Hoppe T, Cassata G, Barral JM, Springer W, Hutagalung AH, Epstein HF, Baumeister R. (2004). Regulation of the Myosin-Directed Chaperone UNC-45 by a Novel E3/E4-Multiubiquitylation Complex in C. elegans. Cell 118, 337-49.

5. Hoppe T, Matuschewski K, Rape M, Schlenker S, Ulrich HD, Jentsch S. (2000). Activation of    a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent     Processing. Cell 102, 577-586.