Publications

2016

Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-specific Manner. Jokic M, Vlasic I, Rinneburger M, Klumper N, Spiro J, Vogel W, Offermann A, Kuempers C, Fritz C, Schmitt A, Riabinska A, Wittersheim M, Michels S, Ozretic L, Florin A, Welcker D, Akyuz MD, Nowak M, Erkel M, Wolf J, Buttner R, Schumacher B, Thomale J, Persigehl T, Maintz D, Perner S, Reinhardt HC. Mol Cancer Res. 2016 Aug 11. pii: molcanres.0094.2016. [Epub ahead of print]

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia. Lohmann G, Vasyutina E, Bloehdorn J, Reinart N, Schneider JI, Babu V, Knittel G, Crispatzu G, Mayer P, Prinz C, Muenzner JK, Biersack B, Efremov DG, Chessa L, Herling CD, Stilgenbauer S, Hallek M, Schobert R, Reinhardt HC, Schumacher B, Herling M. Leukemia. 2016 Dec 2. doi: 10.1038/leu.2016.294. [Epub ahead of print]

Current strategies to create tailored and risk-adapted therapies for CLL patients. Cramer P, Eichhorst B, Reinhardt HC, Hallek M. Best Pract Res Clin Haematol. 2016 Mar;29(1):111-121. doi: 10.1016/j.beha.2016.08.010. Review.

Rewired NFκB signaling as a potentially actionable feature of activated B-cell-like diffuse large B-cell lymphoma. Knittel G, Liedgens P, Korovkina D, Pallasch CP, Reinhardt HC. Eur J Haematol. 2016 Dec;97(6):499-510. doi: 10.1111/ejh.12792. Review.

Dual TORK/DNA-PK inhibition blocks critical signalling pathways in chronic lymphocytic leukemia. Thijssen R, ter Burg J, Garrick B, van Bochove GGW, Brown JR, Fernendes SM, Rodriguez M, Michot JM, Hallek M, Eichhorst BF, Reinhardt HC, Bendell J, Derks IAM, van Kampen R, Hege K, Kersten MJ, Trowe T, Filvaroff E, Eldering E, Kater A: Blood, accepted for publication

Complex karyotypes, KRAS and POT1 mutations impact outcome in CLL after chlorambucil based chemo- or chemoimmunotherapy. Herling CD, Klaumünzer M, Krings Rocha C, Altmüller J, Thiele H, Bahlo J, Kluth S, Crispatzu G, Herling M, Schiller J, Engelke A, Tausch E, Döhner H, Fischer K, Goede V, Nürnberg P, Reinhardt HC, Stilgenbauer S, Hallek M, Kreuzer K: Blood, in press

B cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B cell lymphoma in mice. Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber ANR, Trümper L, ICGC MMML-Seq Consortium, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC: Blood, in press

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Franz A, Pirson PA, Halder S, Pilger D, Achuthankutty D, Kashkar H, Ramadan K, Hoppe T. Nat. Commun. 2016 Feb 4;7:10612. doi: 10.1038/ncomms10612.

Concepts of Chronic Lymphocytic Leukemia Pathogenesis: DNA Damage Response and Tumor Microenvironment. Frenzel LP, Reinhardt HC, Pallasch CP: Oncol Res Treat, DOI:10.1159/000443820, published online Jan. 22. 2016

Exome sequencing identifies potential novel candidate genes in patients with unexplained colorectal adenomatous polyposis. Spier I, Kerick M, Drichel D, Horpaopan S, Altmüller J, Laner A, Holzapfel S, Peters S, Adam R, Zhao B, Becker T, Lifton RP, Holinski-Feder E, Perner S, Thiele H, Nöthen MM, Hoffmann P, Timmermann B, Schweiger MR, Aretz S: Fam Cancer. 2016 Jan 16

A novel recombinant anti-CD22 immunokinase delivers pro-apoptotic activity of death-associated protein kinase (DAPK) and mediates cytotoxicity in neoplastic B-cells. Lilienthal N, Lohmann G, Crispatzu G, Vasyutina E, Zittrich S, Mayer P, Herling CD, Tur MK, Hallek M, Pfitzer G, Barth S, Herling M. Mol Cancer Ther, 2016 Jan 29. pii: molcanther.0685.2015. [Epub ahead of print]

Re-activation of mitochondrial apoptosis inhibits T cell lymphoma survival and treatment resistance. Spinner S, Crispatzu G, Yi JH, Munkhbaatar E, Mayer P, Höckendorf U, Müller N, Li Z, Schader T, Bendz H, Hartmann S, Yabal M, Pechloff K, Heikenwalder M, Kelly GL, Strasser A, Peschel C, Hansmann ML, Ruland J, Keller U, Newrzela S, Herling M*, Jost PJ*. Leukemia (accepted, in press) (* shared senior authorship, order as published);

Treatment of early stage CLL: What is the current evidence? Langerbeins P, Groß-Ophoff-Müller C, Herling CD: Oncol Res Treat, 2016; published online Jan 22. DOI: 10.1159/000443013.

Systemic DNA damage responses in aging and diseases. Ribezzo F, Shiloh Y, Schumacher B. Semin Cancer Biol. 2016 Jan 7. pii: S1044-579X(15)30005-5. doi: 10.1016/j.semcancer.2015.12.005. Jan 7.

Putative Prostate Cancer Risk SNP in an Androgen Receptor-Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites. Bu H, Narisu N, Schlick B, Rainer J, Manke T, Schäfer G, Pasqualini L, Chines P, Schweiger MR, Fuchsberger C, Klocker H: Hum Mutat. 2016 Jan;37(1):52-64. doi: 10.1002/humu.22909. Epub  2015 Oct 19.

2015

ENaC Dysregulation Through Activation of MEK1/2 Contributes to Impaired Na+ Absorption in Lymphocytic Colitis. Barmeyer C, Erko I, Fromm A, Bojarski C, Loddenkemper C, Dames P, Kerick M, Siegmund B, Fromm M, Schweiger MR, Schulzke JD. Inflamm Bowel Dis. 2015 Dec 9.

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group. Vollbrecht C., Werner R., Walter R. F., Christoph D. C., Heukamp L. C., Peifer M., Hirsch B., Burbat L., Mairinger T., Kurt Werner S., Wohlschlaeger J., Mairinger F. D. British Journal of Cancer 113: 1704-1711, 2015. Dec 22.

Double-edged alliance: mitochondrial surveillance by the UPS and autophagy. Franz A., Kevei É., Hoppe T. (2015). Curr Opin Cell Biol. 4, 37:18-27. 2015 Dec. Review.

Editorial: Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets. van Vugt MATM, Reinhardt HC: Frontiers in Genetics, 2015 Dec 22, doi: 10.3389/fgene.2015.00355

Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery. Buchholz CJ, Friedel T, Büning H. Trends Biotechnol. 2015 Dec;33(12):777-90. doi: 10.1016/j.tibtech.2015.09.008. Epub 2015 Oct 20. Review.

Engineering the AAV capsid to optimize vector-host-interactions. Büning H, Huber A, Zhang L, Meumann N, Hacker U. Curr Opin Pharmacol. 2015 Oct;24:94-104. doi: 10.1016/j.coph.2015.08.002. Epub 2015 Aug 25. Review.

Cetuximab Reconstitutes Pro-Inflammatory Cytokine Secretions and Tumor-Infiltrating Capabilities of sMICA-Inhibited NK Cells in HNSCC Tumor Spheroids. Klöss S, Chambron N, Gardlowski T, Weil S, Koch J, Esser R, Pogge von Strandmann E, Morgan MA, Arseniev L, Seitz O, Köhl U. Front Immunol. 2015 Nov 2;6:543. doi: 10.3389/fimmu.2015.00543. eCollection 2015.

NKp30 and its ligands: emerging players in tumor immune evasion from natural killer cells. Pogge von Strandmann E, Shatnyeva O, Hansen HP. Ann Transl Med. 2015 Nov;3(20):314. doi: 10.3978/j.issn.2305-5839.2015.09.08. No abstract available.

Adeno-associated Vector Toxicity-To Be or Not to Be? Büning H, Schmidt M. Mol Ther. 2015 Nov;23(11):1673-5. doi: 10.1038/mt.2015.182. No abstract available. PMID: 26606658

Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases. Spier I, Drichel D, Kerick M, Kirfel J, Horpaopan S, Laner A, Holzapfel S, Peters S, Adam R, Zhao B, Becker T, Lifton RP, Perner S, Hoffmann P, Kristiansen G, Timmermann B, Nöthen MM, Holinski-Feder E, Schweiger MR, Aretz S: J Med Genet. 2015 Nov 27.

Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Peifer M., Hertwig F., Roels F., Dreidax D., Gartlgruber M., Menon R., Kramer A., Roncaioli J. L., Sand F., Heuckmann J. M., Ikram F., Schmidt R., Ackermann S., Engesser A., Kahlert Y., Vogel W., Altmuller J., Nurnberg P., Thierry-Mieg J., Thierry-Mieg D., Mariappan A., Heynck S., Mariotti E., Henrich K. O., Gloeckner C., Bosco G., Leuschner I., Schweiger M. R., Savelyeva L., Watkins S. C., Shao C., Bell E., Hofer T., Achter V., Lang U., Theissen J., Volland R., Saadati M., Eggert A., de Wilde B., Berthold F., Peng Z., Zhao C., Shi L., Ortmann M., Buttner R., Perner S., Hero B., Schramm A., Schulte J. H., Herrmann C., O'Sullivan R. J., Westermann F., Thomas R. K., Fischer M. Nature 526: 700-704, 2015. Oct 29.

Mutations driving CLL and their evolution in progression and relapse. Landau, D.A., Tausch, E., Taylor-Weiner, A.N., Stewart, C., Reiter, J.G., Bahlo, J., Kluth, S., Bozic, I., Lawrence, M., Bottcher, S., Carter, S.L., Cibulskis, K., Mertens, D., Sougnez, C.L., Rosenberg, M., Hess, J.M., Edelmann, J., Kless, S., Kneba, M., Ritgen, M., Fink, A., Fischer, K., Gabriel, S., Lander, E.S., Nowak, M.A., Dohner, H., Hallek, M., Neuberg, D., Getz, G., Stilgenbauer, S., and Wu, C.J. (2015). Nature 526, 525-530. 2015 Oct 22.

Long term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial. Fischer, K., Bahlo, J., Fink, A.M., Goede, V., Herling, C.D., Cramer, P., Langerbeins, P., von Tresckow, J., Engelke, A., Maurer, C., Kovacs, G., Herling, M., Tausch, E., Kreuzer, K.A., Eichhorst, B., Bottcher, S., Seymour, J.F., Ghia, P., Marlton, P., Kneba, M., Wendtner, C.M., Dohner, H., Stilgenbauer, S., and Hallek, M. (2015). Blood127, 208-215. Epub 2015 Oct 20.

Identification of ageing-associated naturally occurring peptides in human urine. Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H. Oncotarget 2015 Oct 27;6(33):34106-17. doi: 10.18632/oncotarget.5896.

Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. Rastetter RH, Blömacher M, Drebber U, Marko M, Behrens J, Solga R, Hojeili S, Bhattacharya K, Wunderlich CM, Wunderlich FT, Odenthal M, Ziemann A, Eichinger L, Clemen CS. (2015) BMC Cancer Sep 15;15:638.

Mutational dynamics between primary and relapse neuroblastomas. Schramm A., Koster J., Assenov Y., Althoff K., Peifer M., Mahlow E., Odersky A., Beisser D., Ernst C., Henssen A. G., Stephan H., Schroder C., Heukamp L., Engesser A., Kahlert Y., Theissen J., Hero B., Roels F., Altmuller J., Nurnberg P., Astrahantseff K., Gloeckner C., De Preter K., Plass C., Lee S., Lode H. N., Henrich K. O., Gartlgruber M., Speleman F., Schmezer P., Westermann F., Rahmann S., Fischer M., Eggert A., Schulte J. H. Nature Genetics 47: 872-877, 2015. August

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. Dietlein F, Kalb B, Jokic M, Noll EM, Strong A, Tharun L, Ozretić L, Künstlinger H, Kambartel K, Randerath WJ, Jüngst C, Schmitt A, Torgovnick A, Richters A, Rauh D, Siedek F, Persigehl T, Mauch C, Bartkova J, Bradley A, Sprick MR, Trumpp A, Rad R, Saur D, Bartek J, Wolf J, Büttner R, Thomas RK, Reinhardt HC. Cell. 2015 Jul 2;162(1):146-59.

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms. Edifizi D, Schumacher B. Biomolecules 2015, 5, 1855-1869; doi:10.3390/biom5031855. Aug 13.

Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome. Seyffert M, Glauser DL, Tobler K, Georgiev O, Vogel R, Vogt B, Agúndez L, Linden M, Büning H, Ackermann M, Fraefel C.J Virol. 2015 Nov;89(21):11150-8. doi: 10.1128/JVI.01370-15. Epub 2015 Aug 19.

miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. Pasqualini L, Bu H, Puhr M, Narisu N, Rainer J, Schlick B, Schäfer G, Angelova M, Trajanoski Z, Börno ST, Schweiger MR, Fuchsberger C, Klocker H. Mol Endocrinol. 2015 Jul;29(7):1037-54.

Activation of KIT modulates the function of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) in mast cells. Förster A, Grotha S, Seeger JM, Rabenhorst A, Gehring M, Raap U, Létard S, Dubreuil P, Kashkar H, Walczak H, Roers A, Hartmann K. Allergy 2015, 70:764-74. Aug

Comprehensive genomic profiles of small cell lung cancer. George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Nature. 2015 Aug 6;524(7563):47-53. doi: 10.1038/nature14664. Epub 2015 Jul 13.

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients. König K., Peifer M., Fassunke J., Ihle M. A., Kunstlinger H., Heydt C., Stamm K., Ueckeroth F., Vollbrecht C., Bos M., Gardizi M., Scheffler M., Nogova L., Leenders F., Albus K., Meder L., Becker K., Florin A., Rommerscheidt-Fuss U., Altmuller J., Kloth M., Nurnberg P., Henkel T., Bikar S. E., Sos M. L., Geese W. J., Strauss L., Ko Y. D., Gerigk U., Odenthal M., Zander T., Wolf J., Merkelbach-Bruse S., Buettner R., Heukamp L. C. Journal of Thoracic 10: 1049-1057, 2015.July

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. Zhang W., Yu Y., Hertwig F., Thierry-Mieg J., Zhang W., Thierry-Mieg D., Wang J., Furlanello C., Devanarayan V., Cheng J., Deng Y., Hero B., Hong H., Jia M., Li L., Lin S. M., Nikolsky Y., Oberthuer A., Qing T., Su Z., Volland R., Wang C., Wang M. D., Ai J., Albanese D., Asgharzadeh S., Avigad S., Bao W., Bessarabova M., Brilliant M. H., Brors B., Chierici M., Chu T. M., Zhang J., Grundy R. G., He M. M., Hebbring S., Kaufman H. L., Lababidi S., Lancashire L. J., Li Y., Lu X. X., Luo H., Ma X., Ning B., Noguera R., Peifer M., Phan J. H., Roels F., Rosswog C., Shao S., Shen J., Theissen J., Tonini G. P., Vandesompele J., Wu P. Y., Xiao W., Xu J., Xu W., Xuan J., Yang Y., Ye Z., Dong Z., Zhang K. K., Yin Y., Zhao C., Zheng Y., Wolfinger R. D., Shi T., Malkas L. H., Berthold F., Wang J., Tong W., Shi L., Peng Z., Fischer M. Genome Biology 16: 133, 2015. Jun 25.

IAP antagonization induces inflammatory destruction of vascular endothelium. Witt A, Seeger JM, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jüngst C, Schauss AC, Schüll S, Wohlleber D, Knolle P, Krönke M, Mauch C, Kashkar H. EMBO Rep. 2015, 16:719-727. Jun

Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing. Vollbrecht C., Mairinger F. D., Koitzsch U., Peifer M., Koenig K., Heukamp L. C., Crispatzu G., Wilden L., Kreuzer K. A., Hallek M., Odenthal M., Herling C. D., Buettner R. PloS One 10: e0129544, 2015 Jun 8.

Heritability estimates on Hodgkin's lymphoma: a genomic- versus population-based approach. Thomsen H, da Silva Filho MI, Försti A, Fuchs M, Ponader S, von Strandmann EP, Eisele L, Herms S, Hofmann P, Sundquist J, Engert A, Hemminki K. Eur J Hum Genet. 2015 Jun;23(6):824-30. doi: 10.1038/ejhg.2014.184. Epub 2014 Sep 17.

Targeting ATM-deficient CLL through interference with DNA repair pathways. Knittel G, Liedgens P, Reinhardt HC. Front Genet. 2015 Jun 10;6:207. doi: 10.3389/fgene.2015.00207. eCollection 2015. Review.

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP. Blood. 2015 May 7;125(19):2948-57

Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Gentileschi MP, Germoni S, Monteleone V, Pellegrino M, Kann M, De Meo PD, Pallocca M, Höpker K, Moretti F, Mattei E, Reinhardt HC, Floridi A, Passananti C, Benzing T, Blandino G, Fanciulli M. Cell Death Dis. 2015 May 21;6:e1764. doi: 10.1038/cddis.2015.117.

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging. Baris OR, Ederer S, Neuhaus JF, von Kleist-Retzow JC, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, Hickethier T, Bunck AC, Stöckigt F, Schrickel JW, Wiesner RJ. (2015) Cell Metab. May 5;21(5):667-77.

Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression. Boucas J, Fritz C, Schmitt A, Riabinska A, Thelen L, Peifer M, Leeser U, Nuernberg P, Altmueller J, Gaestel M, Dieterich C, Reinhardt HC. PLoS One. 2015 May 20;10(5):e0125745. doi: 10.1371/journal.pone.0125745. eCollection 2015.

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel LP. Leukemia. 2015 Apr;29(4):981-4. doi: 10.1038/leu.2014.320. Epub 2014 Nov 7.

A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma. Rothe A, Sasse S, Topp MS, Eichenauer DA, Hummel H, Reiners KS, Dietlein M, Kuhnert G, Kessler J, Buerkle C, Ravic M, Knackmuss S, Marschner JP, Pogge von Strandmann E, Borchmann P, Engert A. Blood. 2015 Jun 25;125(26):4024-31. doi: 10.1182/blood-2014-12-614636. Epub 2015 Apr 17.

Impact of the MRN Complex on Adeno-Associated Virus Integration and Replication during Coinfection with Herpes Simplex Virus 1. Millet R, Jolinon N, Nguyen XN, Berger G, Cimarelli A, Greco A, Bertrand P, Odenthal M, Büning H, Salvetti A. J Virol. 2015 Jul;89(13):6824-34. doi: 10.1128/JVI.00171-15. Epub 2015 Apr 22.

A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency.Liu C, Ding H, Li X, Pallasch CP, Hong L, Guo D, Chen Y, Wang D, Wang W, Wang Y, Hemann MT, Jiang H. EMBO Mol Med. 2015 Mar 9;7(4):438-49.

Adeno-Associated Viral Vectors at the Frontier between Tolerance and Immunity. Mingozzi F, Büning H. Front Immunol. 2015 Mar 17;6:120. doi: 10.3389/fimmu.2015.00120. eCollection 2015. No abstract available.

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H. Cell Death Dis. 2015, 6:e1691 Mar 12.

Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer. Kloth M., Ruesseler V., Engel C., Koenig K., Peifer M., Mariotti E., Kuenstlinger H., Florin A., Rommerscheidt-Fuss U., Koitzsch U., Wodtke C., Ueckeroth F., Holzapfel S., Aretz S., Propping P., Loeffler M., Merkelbach-Bruse S., Odenthal M., Friedrichs N., Heukamp L. C., Zander T., Buettner R. Gut 10.1136/gutjnl-2014-309026, 2015. Apr 28.

Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells. Göckeritz E, Kerwien S, Baumann M, Wigger M, Vondey V, Neumann L, Landwehr T, Wendtner CM, Klein C, Liu N, Hallek M, Frenzel LP, Krause G. Int J Cancer. 2015 Apr 24. doi: 10.1002/ijc.29579. [Epub ahead of print]

NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Wensveen FM, Jelenčić V, Valentić S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Polić B.(2015) Nat Immunol. Apr;16(4):376-85.

DNA repair mechanisms in cancer development and therapy. Torgovnick A, Schumacher B. Front Genet. 2015 Apr 23;6:157. doi: 10.3389/fgene.2015.00157.

Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms. Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A (2015) Dis Model Mech. 2015 Apr;8(4):403-15.

Wormpath: searching for molecular interaction networks in Caenorhabditis elegans. Frommolt P, Schumacher B. Source Code Biol Med. 2015 Apr 2;10:5. doi: 10.1186/s13029-015-0034-6. eCollection 2015.

DNA damage response and evasion from immunosurveillance in CLL: new options for NK cell-based immunotherapies. Shatnyeva OM, Hansen HP, Reiners KS, Sauer M, Vyas M, von Strandmann EP. Front Genet. 2015 Feb 4;6:11. doi: 10.3389/fgene.2015.00011. eCollection 2015.

Regulation of the DNA damage response by ubiquitin conjugation. Brinkmann K., Schell M., Hoppe T.*, Kashkar H. (2015). Front. Genet. 6, 98. (*co-corresponding author) 2015 Mar. Review.

Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalization without inducing empty basement membrane sleeves in xenograft tumors. Coutelle O, Schiffmann LM, Liwschitz M, Brunold M, Goede V, Hallek M, Kashkar H*, Hacker UT*. Br J Cancer 2015, Feb 3, 112:495-503 *equal contribution

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in chronic lymphocytic leukemia. Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP. Blood. 2015 Feb 10.

Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors. Münch RC, Muth A, Muik A, Friedel T, Schmatz J, Dreier B, Trkola A, Plückthun A, Büning H, Buchholz CJ. Nat Commun. 2015 Feb 10;6:6246. doi: 10.1038/ncomms7246.

Longevity through DNA damage tolerance. Castells-Roca L, Mueller M, Schumacher B. Cell Cycle. 2015;14(4):467-8. doi: 10.1080/15384101.2015.1006543.

Quality control mechanisms in cellular and systemic DNA damage responses. Ermolaeva MA, Dakhovnik A, Schumacher B. Ageing Res Rev. 2015 Jan 2. pii: S1568-1637(14)00144-5. doi: 10.1016/j.arr.2014.12.009.

Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Fernandez-Cuesta L., Sun R., Menon R., George J., Lorenz S., Meza-Zepeda L. A., Peifer M., Plenker D., Heuckmann J. M., Leenders F., Zander T., Dahmen I., Koker M., Schottle J., Ullrich R. T., Altmuller J., Becker C., Nurnberg P., Seidel H., Bohm D., Goke F., Ansen S., Russell P. A., Wright G. M., Wainer Z., Solomon B., Petersen I., Clement J. H., Sanger J., Brustugun O. T., Helland A., Solberg S., Lund-Iversen M., Buettner R., Wolf J., Brambilla E., Vingron M., Perner S., Haas S. A., Thomas R. K. Genome Biology 16: 7, 2015. Jan 5.

CD4+ T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation. Holtick U*, Frenzel LP*, Shimabukuro-Vornhagen A, Theurich S, Claasen J, Scheid C, von Bergwelt-Baildon M, Fröhlich H, Wendtner CM, Chemnitz JM. Ann Hematol. 2015 Jan;94(1):129-37. (*equal contribution)

2014

Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy. Dietlein F, Reinhardt HC. Clin Cancer Res. 2014 Dec 1;20(23):5882-7. doi: 10.1158/1078-0432.CCR-14-1165. Review.

C. elegans homolog of the Cockayne syndrome complementation group A gene. Babu V, Hofmann K, Schumacher B. A DNA Repair 2014 Dec:24:57-62. doi: 10.1016/j.dnarep.2014.09.012

Prognostic serum cytokines in classical Hodgkin lymphoma--letter. Coutelle O, Büning H, Plütschow A, Fuchs M, Escalona-Espinosa L, Engert A, Hacker U. Clin Cancer Res. 2014 Dec 15;20(24):6633. doi: 10.1158/1078-0432.CCR-14-1735. No abstract available.

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brönneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brüning JC. (2014) Cell Rep. Nov 20;9(4):1495-506.

DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Mueller M, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B. Nat Cell Biol. 2014 Nov 24:16(12):1168–1179. doi: 10.1038/ncb3071

Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity. Shimabukuro-Vornhagen A, Zoghi S, Liebig TM, Wennhold K, Chemitz J, Draube A, Kochanek M, Blaschke F, Pallasch C, Holtick U, Scheid C, Theurich S, Hallek M, von Bergwelt-Baildon MS. J Immunol. 2014 Nov 15;193(10):5294-305.

Challenging muscle homeostasis uncovers novel chaperone interactions in C. elegans. Frumkin A., Dror S., Pokrzywa W., Bar-Lavan Y., Karady I., Hoppe T., Ben-Zvi A. (2014). Front. Mol. Bio. 6, 1:21. 2014 Nov 6.

MicroRNAs meet calcium: Joint venture in ER proteostasis. Finger F. and Hoppe T. (2014). Sci. Signal. 7, re11.2014 Nov. Review.

Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC.(2014) Cell Metab. Oct 7;20(4):678-86.

CD74-NRG1 fusions in lung adenocarcinoma. Fernandez-Cuesta L., Plenker D., Osada H., Sun R., Menon R., Leenders F., Ortiz-Cuaran S., Peifer M., Bos M., Dassler J., Malchers F., Schottle J., Vogel W., Dahmen I., Koker M., Ullrich R. T., Wright G. M., Russell P. A., Wainer Z., Solomon B., Brambilla E., Nagy-Mignotte H., Moro-Sibilot D., Brambilla C. G., Lantuejoul S., Altmuller J., Becker C., Nurnberg P., Heuckmann J. M., Stoelben E., Petersen I., Clement J. H., Sanger J., Muscarella L. A., la Torre A., Fazio V. M., Lahortiga I., Perera T., Ogata S., Parade M., Brehmer D., Vingron M., Heukamp L. C., Buettner R., Zander T., Wolf J., Perner S., Ansen S., Haas S. A., Yatabe Y., Thomas R. K. Cancer Discovery 4: 415-422, 2014.Apr

BID-mediated release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich C, Brinkmann K, Broxtermann PN, Witt A., Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Koch A, Wunderlich, FT, Villunger A, Martins LM, Krönke M, Kufer T, Utermöhlen O, Kashkar HEMBO J. 2014, 33:2171-2187 Oct 1.

Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome. Zemojtel T, Köhler S, Mackenroth L, Jäger M, Hecht J, Krawitz P, Graul-Neumann L, Doelken S, Ehmke N, Spielmann M, Oien NC, Schweiger MR, Krüger U, Frommer G, Fischer B, Kornak U, Flöttmann R, Ardeshirdavani A, Moreau Y, Lewis SE, Haendel M, Smedley D, Horn D, Mundlos S, Robinson PN. Sci Transl Med. 2014 Sep 3;6(252):252ra123.

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B. Bonizec M., Herissant L., Pokrzywa W., Geng F., Wenzel S., Howard G.C., Rodriguez P., Krause S., Tansey W.P., Hoppe T., Dargemont C. (2014). Nucleic Acids Res. 42, 10975-86. Epub Sep 2014.

The cofilin phosphatase Slingshot Homolog 1 (SSH1) links NOD1 signalling to actin remodeling. Bielig H, Lautz K, Braun PR, Menning M, Machuy N, Brügmann C, Barisic S, Eisler SA, Andree M, Kashkar H, Zurek B, Hausser A, Sansonetti PJ, Meyer TF, Kufer TA. PLoS pathogens 2014, Sep, 10:e1004351

Proteome analysis in the assessment of ageing. Nkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P, Schumacher B. Ageing Res Rev. 2014 Sep 22. pii: S1568-1637(14)00105-6. doi:10.1016/j.arr.2014.09.002.

A chemical switch for controlling viral infectivity. Hörner M, Kaufmann B, Cotugno G, Wiedtke E, Büning H, Grimm D, Weber W. Chem Commun (Camb). 2014 Sep 14;50(71):10319-22. doi: 10.1039/c4cc03292f.

Limited Proteolysis: DisRUPting Proteasomal Inhibition. Hoppe T. (2014). Curr Biol. 24, R693-5. 2014 Aug .Review.

The N-terminal domain of NLRC5 confers transcriptional activity for MHC class I and II gene expression. Neerincx A, Jakobshagen K, Utermöhlen O, Büning H, Steimle V, Kufer TA. J Immunol. 2014 Sep 15;193(6):3090-100. doi: 10.4049/jimmunol.1401065. Epub 2014 Aug 15.

Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches. Dietlein F, Thelen L, Reinhardt HC. Trends Genet. 2014 Aug;30(8):326-39. doi: 10.1016/j.tig.2014.06.003. Epub 2014 Jul 10. Review.

A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling. Köhler A, Demir U, Kickstein E, Krauss S, Aigner J, Aranda-Orgillés B, Karagiannidis AI, Achmüller C, Bu H, Wunderlich A, Schweiger MR, Schaefer G, Schweiger S, Klocker H, Schneider R. Mol Cancer. 2014 Jun 9;13:146.

Activation of the ER unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Hou N.S., Gutschmidt A., Choi D.Y., Pather K., Shi X., Watts J.L., Hoppe T., Taubert S. (2014). Proc. Natl. Acad. Sci. 111, E2271-80., 2014 Jun3.

Reversible 26S Proteasome disassembly upon mitochondrial stress. Livnat-Levanon N., Kevei E., Kleifeld O., Krutauz D., Segref A., Rinaldi T., Erpapazoglou Z., Cohen M., Reis N., Hoppe T., Glickman M.H. (2014). Cell Rep. 7, 1371-80., 2014 Jun 12

T cell-intrinsic role of IL-6 signaling in primary and memory responses. Nish SA, Schenten D, Wunderlich FT, Pope SD, Gao Y, Hoshi N, Yu S, Yan X, Lee HK, Pasman L, Brodsky I, Yordy B, Zhao H, Brüning J, Medzhitov R. (2014) Elife.  May 19;3:e01949. the authors equally contributed to this work.

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC. (2014) Nat Immunol. May;15(5):423-30.

A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC. Dietlein F, Thelen L, Jokic M, Jachimowicz RD, Ivan L, Knittel G, Leeser U, van Oers J, Edelmann W, Heukamp LC, Reinhardt HC: Cancer Discovery, 2014 May;4(5):592-605.

Hexosamine pathway metabolites enhance protein quality control and prolong life. Denzel M.S., Storm N.J., Gutschmidt A., Baddi R., Hinze Y., Jarosch E., Sommer T., Hoppe T., Antebi A. (2014). Cell 156, 1167-78. 2014 Mar 13.

Incorporating targeted agents into future therapy of chronic lymphocytic leukemia. Pallasch CP, Hallek M. Semin Hematol. 2014 Jul;51(3):235-48. doi: 10.1053/j.seminhematol.2014.05.005. Epub 2014 May 15. Review.

Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30. Schlecker E, Fiegler N, Arnold A, Altevogt P, Rose-John S, Moldenhauer G, Sucker A, Paschen A,von Strandmann EP, Textor S, Cerwenka A. Cancer Res. 2014 Jul 1;74(13):3429-40. doi: 10.1158/0008-5472.CAN-13-3017. Epub 2014 Apr 29.

Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Segref A., Kevei E., Pokrzywa W., Schmeisser K., Mansfeld J., Livnat-Levanon N., Ensenauer R., Glickman M.H., Ristow M., Hoppe T. (2014). Cell Metab. 19, 642-52. 2014 Apr 1.

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Liwschitz M, Seeger JM, Piekarek M, Brinkmann K, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT and Kashkar H. EMBO Mol. Med. 2014, 6:624-639 

CGARS: cancer genome analysis by rank sums. Lu X., Thomas R. K., Peifer M. Bioinformatics 30: 1295-1296, 2014. May

The C. elegans model for innate immunity. Ermolaeva MA, Schumacher B. Insights from the worm: Semin Immunol. 2014 May 20. pii: S1044-5323(14)00051-7. doi: 10.1016/j.smim.2014.04.005.

The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. Hussong M, Börno ST, Kerick M, Wunderlich A, Franz A, Sültmann H, Timmermann B, Lehrach H, Hirsch-Kauffmann M, Schweiger MR. Cell Death Dis. 2014 Apr 24;5:e1195.

Loss of C. elegans BRCA1 promotes genome stability during replication in smc-5 mutants. Wolters S, Ermolaeva M, Bickel J, Fingerhut J, Khanikar J, Chan R, Schumacher B. Genetics. 2014 Apr;196(4):985-99. doi: 10.1534/genetics.113.158295

Ubiquitin sets the timer: impacts on aging and longevity. Kevei E. and Hoppe T. (2014). Nat Struct Mol Biol. 21, 290-2. Review. 2014 Apr.

Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo. Hösel M, Lucifora J, Michler T, Holz G, Gruffaz M, Stahnke S, Zoulim F, Durantel D, Heikenwalder M, Nierhoff D, Millet R, Salvetti A, Protzer U, Büning H. Hepatology. 2014 Jun;59(6):2110-20. doi: 10.1002/hep.26990. Epub 2014 Apr 30.

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Fernandez-Cuesta L., Peifer M., Lu X., Sun R., Ozretic L., Seidel D., Zander T., Leenders F., George J., Muller C., Dahmen I., Pinther B., Bosco G., Konrad K., Altmuller J., Nurnberg P., Achter V., Lang U., Schneider P. M., Bogus M., Soltermann A., Brustugun O. T., Helland A., Solberg S., Lund-Iversen M., Ansen S., Stoelben E., Wright G. M., Russell P., Wainer Z., Solomon B., Field J. K., Hyde R., Davies M. P., Heukamp L. C., Petersen I., Perner S., Lovly C. M., Cappuzzo F., Travis W. D., Wolf J., Vingron M., Brambilla E., Haas S. A., Buettner R., Thomas R. K. Nature Communications 5: 3518, 2014. Mar.

Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity. Geibel M, Badurek S, Horn JM, Vatanashevanopakorn C, Koudelka J, Wunderlich CM, Brönneke HS, Wunderlich FT, Minichiello L.(2014)  Nat Commun. Mar 12;5:3427.

Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing. Brinkmann K, Hombach A, Seeger JM, Wagner-Stippich D, Klubertz D, Krönke M, Abken H, and Kashkar H. Leuk Lymphoma 2014, Mar, 55:645-651

Protrusion-guided extracellular vesicles mediate CD30 trans-signalling in the microenvironment of Hodgkin's lymphoma. Hansen HP, Engels HM, Dams M, Paes Leme AF, Pauletti BA, Simhadri VL, Dürkop H, Reiners KS, Barnert S, Engert A, Schubert R, Quondamatteo F, Hallek M, Pogge von Strandmann E. J Pathol. 2014 Mar;232(4):405-14. doi: 10.1002/path.4306.

Role of Exosomes Released by Dendritic Cells and/or by Tumor Targets: Regulation of NK Cell Plasticity. Reiners KS, Dassler J, Coch C, Pogge von Strandmann E. Front Immunol. 2014 Mar 7;5:91. doi: 10.3389/fimmu.2014.00091. eCollection 2014. Review.

Massive air embolism following lung biopsy. Franke M, Reinhardt HC, v. Bergwelt-Baildon M, Bangard C: Circulation, 2014 Mar 4;129(9):1046-7.

IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions. Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A. (2014) J Invest Dermatol. Mar;134(3):728-35.

A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC. Dietlein F, Thelen L, Jokic M, Jachimowicz RD, Ivan L, Knittel G, Leeser U, van Oers J, Edelmann W, Heukamp LC, Reinhardt HC. Cancer Discov. 2014 Feb 20.

S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Fröhlich M, Dejanovic B, Kashkar H, Schwarz G, Nussberger S. Cell Death Dis. 2014 Feb, 5:e1057

Impact of genomic damage and ageing on stem cell function. Behrens A, van Deursen JM, Rudolph KL, Schumacher B. Nat Cell Biol. 2014 Feb 28;16(3):201-7.

Systemic DNA damage responses: organismal adaptations to genome instability. Ermolaeva MA, Schumacher B. Trends Genet. 2014 Mar;30(3):95-102. doi: 10.1016/j.tig.2013.12.001. Epub 2014 Jan 15. Review.

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, Medzhitov R. (2014) Immunity. Jan 16;40(1):78-90.

Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Sommer D, Peters A, Wirtz T, Mai M, Ackermann J, Thabet Y, Schmidt J, Weighardt H, Wunderlich FT, Degen J, Schultze JL, Beyer M. (2014) Nat Commun. 5:3045.

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions. Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM, Chagorova T, de la Serna J, Dilhuydy MS, Illmer T, Opat S, Owen CJ, Samoylova O, Kreuzer KA, Stilgenbauer S, Döhner H, Langerak AW, Ritgen M, Kneba M, Asikanius E, Humphrey K, Wenger M, Hallek M. N Engl J Med. 2014 Jan 8.

Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia. Furman RR, Sharman JP, Coutre SE, Cheson BD, Pagel JM, Hillmen P, Barrientos JC, Zelenetz AD, Kipps TJ, Flinn I, Ghia P, Eradat H, Ervin T, Lamanna N, Coiffier B, Pettitt AR, Ma S, Stilgenbauer S, Cramer P, Aiello M, Johnson DM, Miller LL, Li D, Jahn TM, Dansey RD, Hallek M, O'Brien SM. N Engl J Med. 2014 Jan 22.

Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy. Sallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H. Mol Ther. 2014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28.

Sensitizing protective tumor microenvironments to antibody-mediated therapy. Pallasch CP, Leskov I, Braun CJ, Vorholt D, Drake A, Soto-Feliciano YM, Bent EH, Schwamb J, Iliopoulou B, Kutsch N, van Rooijen N, Frenzel LP, Wendtner CM, Heukamp L, Kreuzer KA, Hallek M, Chen J, Hemann MT. Cell. 2014 Jan 30;156(3):590-602.

Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP. Franz A., Ackermann L., Hoppe T. (2014). Biochim Biophys Acta. 1843, 205-15. Review. 2014 Jan

2013

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer. Malchers F, Dietlein F, Schöttle J, Lu X, Nogova L, Albus K, Fernandez-Cuesta L, Heuckmann JM, Gautschi O, Diebold J, Plenker D, Gardizi M, Scheffler M, Bos M, Seidel D, Leenders F, Richters A, Peifer M, Florin A, Mainkar PS, Karre N, Chandrasekhar S, George J, Silling S, Rauh D, Zander T, Ullrich R, Reinhardt HC, Ringeisen F, Büttner R, Heukamp LC, Wolf J, Thomas RK: Cancer Discovery, Published Online First December 3, 2013; doi:10.1158/2159-8290.

The innate immune system as mediator of systemic DNA damage responses. Ermolaeva M, Schumacher B.Commun Integr Biol. 2013 Nov 13;6(6):e26926. doi: 10.4161/cib.26926

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Schmeisser K., Mansfeld J., Kuhlow D., Weimer S., Priebe S., Heiland I., Birringer M., Groth M., Segref A., Kanfi Y., Price N.L., Schmeisser S., Schuster S., Pfeiffer A.F., Guthke R., Platzer M., Hoppe T., Cohen H.Y., Zarse K., Sinclair D.A., Ristow M. (2013). Nat Chem Biol. 9, 693-700. 2013 Nov13.

A novel Cre-versible approach identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Jacks T, Yaffe MB: Cell Reports, 2013 Nov 13. doi:pii: S2211-1247(13)00609-8. 10.1016/j.celrep.2013.10.025.

The histone deacetylase inhibitor LBH589 (panobinostat) modulates the crosstalk of lymphocytes with Hodgkin lymphoma cell lines. Klein JM, Henke A, Sauer M, Bessler M, Reiners KS, Engert A, Hansen HP, von Strandmann EP. PLoS One. 2013 Nov 21;8(11):e79502. doi: 0.1371/journal.pone.0079502. eCollection 2013.

Natural ligands and antibody-based fusion proteins: harnessing the immune system against cancer. Vyas M, Koehl U, Hallek M, von Strandmann EP. Trends Mol Med. 2014 Feb;20(2):72-82. doi: 10.1016/j.molmed.2013.10.006. Epub 2013 Nov 19. Review.

Regulation of self-ligands for activating natural killer cell receptors. Lam RA, Chwee JY, Le Bert N, Sauer M, Pogge von Strandmann E, Gasser S. Ann Med. 2013 Jun;45(4):384-94.

Somatic copy number alterations by whole-exome sequencing implicates YWHAZ and PTK2 in castration-resistant prostate cancer. Menon R., Deng M., Ruenauver K., Queisser A., Peifer M., Offermann A., Boehm D., Vogel W., Scheble V., Fend F., Kristiansen G., Wernert N., Oberbeckmann N., Biskup S., Rubin M. A., Shaikhibrahim Z., Perner S. The Journal of Pathology 231: 505-516, 2013. Dec

Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity. Reiners KS, Topolar D, Henke A, Simhadri VR, Kessler J, Sauer M, Bessler M, Hansen HP, Tawadros S, Herling M, Krönke M, Hallek M, Pogge von Strandmann E. Blood. 2013 May 2;121(18):3658-65.

A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo. Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB. Cell Rep. 2013 Nov 13. 

Dimethylfumarate induces apoptosis in human mast cells. Förster A, Preussner LM, Seeger JM, Rabenhorst A, Kashkar H, Mrowietz U, Hartmann K, Exp. Dermatol. 2013, Nov, 22:719-724

A genomics-based classification of human lung tumors. Seidel D, Zander T, Heukamp LC, Peifer M, Bos M, Fernández-Cuesta L, Leenders F, Lu X, Ansén S, Gardizi M, Nguyen C, Berg J, Russell P, Wainer Z, Schildhaus HU, Rogers TM, Solomon B, Pao W, Carter SL, Getz G, Hayes D, Wilkerson MD, Thunnissen E, Travis WD, Perner S, Wright G, Brambilla E, Büttner R, Wolf J, Thomas RK, Gabler F, Wilkening I, Müller C, Dahmen I, Menon R, König K, Albus K, Merkelbach-Bruse S, Fassunke J, Schmitz K, Kuenstlinger H, Kleine MA, Binot E, Querings S, Altmüller J, Bäßmann I, Nürnberg P, Schneider PM, Bogus M, Büttner R, Perner S, Russell P, Thunnissen E, Travis WD, Brambilla E, Soltermann A, Moch H, Brustugun OT, Solberg S, Lund-Iversen M, Helland Å, Muley T, Hoffmann H, Schnabel PA, Chen Y, Groen H, Timens W, Sietsma H, Clement JH, Weder W, Sänger J, Stoelben E, Ludwig C, Engel-Riedel W, Smit E, Heideman DA, Snijders PJ, Nogova L, Sos ML, Mattonet C, Töpelt K, Scheffler M, Goekkurt E, Kappes R, Krüger S, Kambartel K, Behringer D, Schulte W, Galetke W, Randerath W, Heldwein M, Schlesinger A, Serke M, Hekmat K, Frank KF, Schnell R, Reiser M, Hünerlitürkoglu AN, Schmitz S, Meffert L, Ko YD, Litt-Lampe M, Gerigk U, Fricke R, Besse B, Brambilla C, Lantuejoul S, Lorimier P, Moro-Sibilot D, Cappuzzo F, Ligorio C, Damiani S, Field JK, Hyde R, Validire P, Girard P, Muscarella LA, Fazio VM, Hallek M, Soria JC, Carter SL, Getz G, Hayes D, Wilkerson MD, Achter V, Lang U, Seidel D, Zander T, Heukamp LC, Peifer M, Bos M, Pao W, Travis WD, Brambilla E, Büttner R, Wolf J, Thomas RK, Büttner R, Wolf J, Thomas RK. Science Translational Medicine 5: 209ra153, 2013.OCT 30

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B. Nature. 2013 Sep 19;501(7467):416-20.

Improving immunotherapy of hepatocellular carcinoma (HCC) using dendritic cells (DC) engineered to express IL-12 in vivo. Vogt A, Sievers E, Lukacs-Kornek V, Decker G, Raskopf E, Meumann N, Büning H, Sauerbruch T, Strassburg CP, Schmidt-Wolf IG, Gonzalez-Carmona MA. Liver Int. 2014 Mar;34(3):447-61. doi: 10.1111/liv.12284. Epub 2013 Sep 2.

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Horwitz JA, Halper-Stromberg A, Mouquet H, Gitlin AD, Tretiakova A, Eisenreich TR, Malbec M, Gravemann S, Billerbeck E, Dorner M, Büning H, Schwartz O, Knops E, Kaiser R, Seaman MS, Wilson JM, Rice CM, Ploss A, Bjorkman PJ, Klein F, Nussenzweig MC. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16538-43. doi: 10.1073/pnas.1315295110. Epub 2013 Sep 16.

Gene therapy on the move. Kaufmann KB, Büning H, Galy A, Schambach A, Grez M. EMBO Mol Med. 2013 Nov;5(11):1642-61. doi: 10.1002/emmm.201202287. Epub 2013 Sep 17. Review.

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Reinhardt HC, Yaffe MB. Nat Rev Mol Cell Biol. 2013 Sep;14(9):563-80.

Signaling the end of chronic lymphocytic leukemia: new frontline treatment strategies. Hallek M. Blood. 2013 Sep 24.

Prediction of poor outcome in CLL patients following first-line treatment with fludarabine, cyclophosphamide and rituximab. Fink AM, Böttcher S, Ritgen M, Fischer K, Pflug N, Eichhorst B, Wendtner CM, Winkler D, Bühler A, Zenz T, Staib P, Mayer J, Hensel M, Hopfinger G, Wenger M, Fingerle-Rowson G, Döhner H, Kneba M, Stilgenbauer S, Busch R, Hallek M. Leukemia. 2013 Sep;27(9):1949-52.

Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment. Hallek M. Am J Hematol. 2013 Sep;88(9):803-16.

K(ATP)-channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis. Tovar S, Paeger L, Hess S, Morgan DA, Hausen AC, Brönneke HS, Hampel B, Ackermann PJ, Evers N, Büning H, Wunderlich FT, Rahmouni K, Kloppenburg P, Brüning JC.(2013) Cell Metab. Sep 3;18

Genomics and epigenomics: new promises of personalized medicine for cancer patients. Schweiger MR, Barmeyer C, Timmermann B.  Brief Funct Genomics. 2013 Sep;12(5):411-21.

Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Rα Signaling. Gruber S, Straub BK, Ackermann PJ, Wunderlich CM, Mauer J, Seeger JM, Büning H, Heukamp L, Kashkar H, Schirmacher P, Brüning JC, Wunderlich FT. Cell Rep. 2013 Aug 29;4(4):669-80.

Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular aging. Schermer B, Bartels V, Frommolt P, Habermann B, Braun F, Schultze JL, Roodbergen M, Hoeijmakers JH, Schumacher B, Nürnberg P, Dollé ME, Benzing T, Müller RU, Kurschat CE. BMC Genomics. 2013 Aug 16;14:559. doi: 10.1186/1471-2164-14-559.

Second-line therapies of patients initially treated with fludarabine and cyclophosphamide or fludarabine, cyclophosphamide and rituximab for chronic lymphocytic leukemia within the CLL8 protocol of the German CLL Study Group. Cramer P, Fink AM, Busch R, Eichhorst B, Wendtner CM, Pflug N, Langerbeins P, Bahlo J, Goede V, Schubert F, Döhner H, Stilgenbauer S, Dreger P, Kneba M, Böttcher S, Mayer J, Hallek M, Fischer K. Leuk Lymphoma. 2013 Aug;54(8):1821-2.

NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG. Schnaiter A, Paschka P, Rossi M, Zenz T, Bühler A, Winkler D, Cazzola M, Döhner K, Edelmann J, Mertens D, Kless S, Mack S, Busch R, Hallek M, Döhner H, Stilgenbauer S. Blood. 2013 Aug 15;122(7):1266-70.

Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular aging. Schermer B, Bartels V, Frommolt P, Habermann B, Braun F, Schultze JL, Roodbergen M, Hoeijmakers JH, Schumacher B, Nürnberg P, Dollé ME, Benzing T, Müller RU, Kurschat CE. BMC Genomics. 2013 Aug 16;14:559

High-throughput miRNA and mRNA sequencing of paired colorectal normal, tumor and metastasis tissues and bioinformatic modeling of miRNA-1 therapeutic applications. Röhr C, Kerick M, Fischer A, Kühn A, Kashofer K, Timmermann B, Daskalaki A, Meinel T, Drichel D, Börno ST, Nowka A, Krobitsch S, McHardy AC, Kratsch C, Becker T, Wunderlich A, Barmeyer C, Viertler C, Zatloukal K, Wierling C, Lehrach H, Schweiger MR. PLoS One. 2013 Jul 2;8(7):e67461.

TNF-Receptor-1 adaptor protein FAN mediates TNF-induced B16 melanoma motility and invasion. Böcke A, Carstens AC, Neacsu CD, Baschuck N, Haubert D, Kashkar H, Utermöhlen O, Pongratz C, Krönke M. Br J Cancer 2013, 109:422-32 epub May 15

Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM-Defective Tumors. Riabinska A, Daheim M, Herter-Sprie GS, Winkler J, Fritz C, Hallek M, Thomas RK, Kreuzer KA, Frenzel LP, Monfared P, Martins-Boucas J, Chen S, Reinhardt HC. Sci Transl Med. 2013 Jun 12;5(189):189ra78.

Induction of the DNA damage response by IAP inhibition triggers natural immunity via upregulation of NKG2D ligands in Hodgkin lymphoma in vitro. Sauer M, Reiners KS, Hansen HP, Engert A, Gasser S, Pogge von Strandmann E. Biol Chem. 2013 Jun 20.

ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer. Kacprzyk LA, Laible M, Andrasiuk T, Brase JC, Börno ST, Fälth M, Kuner R, Lehrach H, Schweiger MR, Sültmann H. PLoS One. 2013;8(3):e59976. Epub Mar

Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing. Brinkmann K, Hombach A, Seeger JM, Wagner-Stippich D, Klubertz D, Krönke M, Abken H, Kashkar H. Leuk Lymphoma. 2013 Jun 26.

The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma. Rothe A, Jachimowicz RD, Borchmann S, Madlener M, Keßler J, Reiners KS, Sauer M, Hansen HP, Ullrich RT, Chatterjee S, Borchmann P, Yazaki P, Koslowsky TC, Engert A, Heukamp LC, Hallek M,von Strandmann EP. Int J Cancer. 2014 Jun 15;134(12):2829-40. doi: 10.1002/ijc.28609. Epub 2013 Nov 29.

Chaperoning myosin assembly in muscle formation and aging. Pokrzywa W., Hoppe T. (2013). Worm. 2, e25644. . Review., 2013 Jul 17.

Regulation of self-ligands for activating natural killer cell receptors. Lam RA, Chwee JY, Le Bert N, Sauer M, Pogge von Strandmann E, Gasser S. Ann Med. 2013 Jun;45(4):384-94.

CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Fedorchenko O, Stiefelhagen M, Peer-Zada AA, Barthel R, Mayer P, Eckei L, Breuer A, Crispatzu G, Rosen N, Landwehr T, Lilienthal N, Möllmann M, Montesinos-Rongen M, Heukamp L, Dürig J, Hallek M, Fingerle-Rowson G, Herling M. Blood. 2013 May 16;121(20):4126-36.

Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity. Wunderlich CM, Hövelmeyer N, Wunderlich FT. (2013) JAKSTAT. Apr 1;2(2):e23878.

Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. Frampton M, da Silva Filho MI, Broderick P, Thomsen H, Försti A, Vijayakrishnan J, Cooke R, Enciso-Mora V, Hoffmann P, Nöthen MM, Lloyd A, Holroyd A, Eisele L, Jöckel KH, Ponader S, von Strandmann EP, Lightfoot T, Roman E, Lake A, Montgomery D, Jarrett RF, Swerdlow AJ, Engert A, Hemminki K, Houlston RS. Nat Commun. 2013;4:2549. doi: 10.1038/ncomms3549.

Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality. Ackermann B, Kröber S, Torres-Benito L, Borgmann A, Peters M, Hosseini Barkooie SM, Tejero R, Jakubik M, Schreml J, Milbradt J, Wunderlich FT, Riessland M, Tabares L, Wirth B.(2013) Hum Mol Genet. Apr 1;22(7):1328-47.

Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils. Förster A, Falcone FH, Gibbs BF, Preussner LM, Fiebig BS, Altunok H, Seeger JM, Cerny-Reiterer S, Rabenhorst A, Papenfuss K, Valent P, Kashkar H, Hartmann K. Leuk Lymphoma. 2013 Apr;54(4):835-42.

A role for PVRL4-driven cell-cell interactions in tumorigenesis. Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. Elife. 2013 Apr 30;2:e00358.

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. Chatterjee S., Heukamp L. C., Siobal M., Schottle J., Wieczorek C., Peifer M., Frasca D., Koker M., Konig K., Meder L., Rauh D., Buettner R., Wolf J., Brekken R. A., Neumaier B., Christofori G., Thomas R. K., Ullrich R. T. The Journal of Clinical Investigation 123: 1732-1740, 2013. Apr

Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells. Bu H, Schweiger MR, Manke T, Wunderlich A, Timmermann B, Kerick M, Pasqualini L, Shehu E, Fuchsberger C, Cato AC, Klocker H. FEBS J. 2013 Mar;280(5):1249-66.

Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Brinkmann K, Zigrino P, Witt A, Schell M, Ackermann L, Broxtermann P, Schüll S, Andree M, Coutelle O, Yazdanpanah B, Seeger JM, Klubertz D, Drebber U, Hacker UT, Krönke M, Mauch C, Hoppe T, Kashkar H. Cell Rep. 2013 Mar 28;3(3):881-91.

A novel interaction between aging and ER overload in a protein conformational dementia. Schipanski A., Lange S., Segref A., Gutschmidt A., Lomas D.A., Miranda E., Schweizer M., Hoppe T.*, Glatzel M. (2013). Genetics 193, 865-76. (*co-corresponding author), 2013 Mar.

Genomics and epigenomics of colorectal cancer. Schweiger MR, Hussong M, Röhr C, Lehrach H. Wiley Interdiscip Rev Syst Biol Med. 2013 Mar-Apr;5(2):205-19.

Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients. Reiners KS, Kessler J, Sauer M, Rothe A, Hansen HP, Reusch U, Hucke C, Köhl U, Dürkop H, Engert A, von Strandmann EP. Mol Ther. 2013 Apr;21(4):895-903. doi: 10.1038/mt.2013.14. Epub 2013 Mar 5.

Galectin-1 serum levels reflect tumor burden and adverse clinical features in classical Hodgkin lymphoma. Ouyang J, Plütschow A, Pogge von Strandmann E, Reiners KS, Ponader S, Rabinovich GA, Neuberg D, Engert A, Shipp MA. Blood. 2013 Apr 25;121(17):3431-3. doi: 10.1182/blood-2012-12-474569. Epub 2013 Feb 26.

Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils. Förster A, Falcone FH, Gibbs BF, Preussner LM, Fiebig BS, Altunok H, Seeger JM, Cerny-Reiterer S, Rabenhors A, Papenfuss K, Valent P, Kashkar H, Hartmann K. Leuk Lymphoma 2013, Apr, 54:835-42

Genomic variation by whole-genome SNP genotyping predicts time-to-event outcome in previously untreated chronic lymphocytic leukemia (CLL). Schweighofer CD, Coombes KR, Majewsky T, Barron LL, Lerner S, O’Brien S, Ferrajoli A, Wierda WG, Czerniak BA, Medeiros LJ, Keating MJ, Abruzzo LV: J Mol Diagn, 2013 Mar; 15(2): 196-209.

Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in mice. Pal M, Wunderlich CM, Spohn G, Brönneke HS, Schmidt-Supprian M, Wunderlich FT. (2013) PLoS One.8(1):e54247.epub Jan 17.

Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy. Peche VS, Holak TA, Burgute BD, Kosmas K, Kale SP, Wunderlich FT, Elhamine F, Stehle R, Pfitzer G, Nohroudi K, Addicks K, Stöckigt F, Schrickel JW, Gallinger J, Schleicher M, Noegel AA. (2013) Cell Mol Life Sci. Feb;70(3):527-43.

DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer. Grimm C, Chavez L, Vilardell M, Farrall AL, Tierling S, Böhm JW, Grote P, Lienhard M, Dietrich J, Timmermann B, Walter J, Schweiger MR, Lehrach H, Herwig R, Herrmann BG, Morkel M. PLoS Genet. 2013;9(2):e1003250.

Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. Yasuda T, Wirtz T, Zhang B, Wunderlich FT, Schmidt-Supprian M, Sommermann T, Rajewsky K. (2013)  Cold Spring Harb Symp Quant Biol. 78:259-63.epub Nov 13

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, Jin C, Wunderlich C, Wunderlich FT, Eisenbarth SC, Flavell RA.(2013) Proc Natl Acad Sci U S A. Jun 11;110(24):9862-7.

Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells. Ruud J, Wilhelms DB, Nilsson A, Eskilsson A, Tang YJ, Ströhle P, Caesar R, Schwaninger M, Wunderlich FT, Bäckhed F, Engblom D, Blomqvist A. (2013) FASEB J. May;27(5):1973-80.

Genome maintenance and transcription integrity in aging and disease.Wolters S and Schumacher B. Front. Genet. 2013 Feb 25; 4:19.

Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies.Leskov I, Pallasch CP, Drake A, Iliopoulou BP, Souza A, Shen CH, Schweighofer CD, Abruzzo L, Frenzel LP, Wendtner CM, Hemann MT, Chen J. Oncogene. 2013 Feb 21;32(8):1066-72.

Gene therapy enters the pharma market: the short story of a long journey. Büning H. EMBO Mol Med. 2013 Jan;5(1):1-3. doi: 10.1002/emmm.201202291. No abstract available.

 Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer.  Münch RC, Janicki H, Völker I, Rasbach A, Hallek M, Büning H, Buchholz CJ. Mol Ther. 2013 Jan;21(1):109-18. doi: 10.1038/mt.2012.186. Epub 2012 Sep 11.

The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Gazda, L., Pokrzywa, W., Hellerschmied, D., Löwe, T., Forné, I., Mueller-Planitz, F., Hoppe, T.*, Clausen, T. (2013). Cell Jan 17, 152, 183-95. (*co-corresponding author)